Interaction in the medical field means how particular medicines act in response to each other. Since we understand Ciprofloxacin is a member of the quinolones class of drugs, synchronized administration or ingesting of Cipro with other quinolones like Theophylline may lead to prominent Theophylline serum concentration and prolonged exclusion of its half-life. The result of this is increased threat of unfavorable reactions that are Theophylline-related. If the use of both Cipro and another quinolones such as Theophylline, serum levels of Theophylline should be closely and regularly monitored and adjustments in the dosage made when appropriate.
As the interaction between the drugs may be good, some cases have Cipro side effects, sometimes severe.
Some of these include:
. Gastrointestinal perforations and pain in the abdominal area.
. Respiratory difficulty and spasms in the bronchus
. Musculoskeletal aches- this refers to joints, chest and neck pains
The CSM (Committee on the Safety of Medicines) and the FDA (US Food and Drug Administration) warn that adverse effects on the central nervous system, such as seizures, may increase. This is due to an interaction between Ciprofloxacin and NSAIDs (non-steroidal anti-inflammatory drug). The interaction between quinolones and NSAIDs is important, because it has the prospective of significant CNS poisoning toxicity. The mechanism and means for this interaction is alleged to be due to a synergy increased rivalry of GABA brain wave transmission.
Medical researchers have found that some quinolones, including ciprofloxacin, have been shown to meddle with the metabolism or breakdown of caffeine. This may advance to reduced digestion and removal of caffeine and a serum’s half-life prolongation. In other words, mixing coffee and the Ciprofloxacin drug may make you stay awake a while longer than expected, since the caffeine is still in the body.
Whether a patient was treated using a fluoroquinolones, like Ciprofloxacin, in recent times or in the past, is in the risk of suffering tendon rapture or tear, mostly affecting the Achilles tendon, located in the posterior of the leg. This usually affects the elderly and it is due to this that the black box warning by the FDA was put. If someone goes against this warning and takes the drug, then he/she should be able to deal with the side effects.
Interaction between Cipro and any other drug containing magnesium, calcium or any form of powder prescribed to children may bring about a lower desire to urinate. This is because the combination or interaction decreases the rate of absorption of products that get into the stomach. Digestion is slowed and thus absorption is momentarily hindered. The related administration of ciprofloxacin with a drug containing sulfonylurea glyburide has resulted in severe hypoglycemia, but on rare occasions. Hypoglycemia is the condition where a patient suffers from low blood sugar levels, usually lower than 70ml/dL.
Ciprofloxacin’s renal clearance or, the way it is ejected from the body, may have an influence on the other drugs subject to renal clearance which will one way or another affect the kidneys. The administration of ciprofloxacin concurrently with cyclosporine has also been associated with brief elevations in serum creatinine, a synthesized product of cretine phosphate which cannot be absorbed back to the body.